The T&T Police Service has issued a public appeal for the members of the public to help locate two of the prison escapees identified as Hassan Atwell and Christopher Selby.
Atwell and Selby were among the prisoners who escaped from the Port-of-Spain Prison earlier today.
Police have concentrated their search for the prisoners in the Belmont district.
A third prisoner, Allan "Scanny" Martin was killed by police near the Port-of-Spain General Hospital.
A police officer who was shot during the gunfight has reportedly died while undergoing surgery, police said.
Earlier panic gripped the city after gunmen opened fire on a passing police patrol near the Port of Spain prison, on Frederick Street during a jailbreak.
Eyewitness said the motionless body was removed from the security guard's booth at the entrance of the hospital.
All entrances and exits have been closed except one at the hospital as police search all vehicles leaving.
Soliders and several units from the Police Service are at the scene. A National Security helicopter is hovering ahead.
Police are searching areas in Belmont for the prison escapees and the gunmen.
Shortly after noon, police said, several gunmen who they believe was waiting in front of the prison to escort the escapees.
TTPS communications officer ASP Michael Pierre said he received information that they were looking for two suspects "possibly more" and a manhunt was launched.
This is a developing story. Come back for updates